One of the key concerns of older adults is the experience of memory loss, especially as it is one of the hallmark symptoms of Alzheimer's disease. However, memory loss is qualitatively different in normal aging from the kind of memory loss associated with a diagnosis of Alzheimer's.^[1]

[edit] Mild cognitive impairment

Recent research has identified a transitional state between the cognitive changes of normal aging and Alzheimer's disease (AD), known as mild cognitive impairment (MCI). Many people who experience mild cognitive impairment are at a high risk of developing Alzheimer's disease. Several studies have indicated that MCI individuals are at an increased risk for developing AD, ranging from 1% to 25% per year; 24% of MCI patients progressed to AD in 2 years and 20% more over 3 years, whereas a recent study indicated that the progression of MCI subjects was 55% in 4.5 years.^[2]

[edit] Memory decline in normal aging

The ability to encode new memories of events or facts and working memory shows decline in both cross-sectional and longitudinal studies.^[3] Studies comparing the effects of aging on episodic memory, semantic memory, short-term memory and priming find that episodic memory is especially impaired in normal aging.^[4] These deficits may be related to impairments seen in the ability to refresh recently processed information.^[5] In addition, even when equated in memory for a particular item or fact, older adults tend to be worse at remembering the source of their information,^[6] a deficit that may be related to declines in the ability to bind information together in memory during encoding and retrieve those associations at a later time.^[7][8]

A postmortem examination of five brains of elderly people with better memory than average'called "super aged" -- found that these individuals had less fiber-like tangles of tau protein than found in typical elderly brains, but a similar amount of amyloid plaque.^[9]

[edit] Domains of memory mostly spared

In contrast, implicit, or procedural memory typically shows no decline with age^[10], short-term memory shows little decline^[4] and semantic knowledge, such as vocabulary, actually improves somewhat with age.^[11] In addition, the enhancement seen in memory for emotional events is also maintained with age.^[12]

[edit] Qualitative changes

Most research on memory and aging has focused on how older adults perform less well at a particular memory task. However, recently researchers have also discovered that simply saying that older adults are doing the same thing, only less of it, is not always accurate. In some cases, older adults seem to be using different strategies than younger adults. For example, brain imaging studies have revealed that older adults are more likely to use both hemispheres when completing memory tasks than younger adults.^[13] In addition, older adults sometimes show a positivity effect when remembering information, which seems to be a result of the increased focus on regulating emotion seen with age.^[12] For instance, eye tracking reveals that older adults showed preferential looking toward happy faces and away from sad faces.^[14]

[edit] See also

• Aging
• Brain aging
• Childhood amnesia
• Cognitive enhancement
• Life extension
• List of life extension related topics
• Memory
• Testamentary capacity
• Matching Person & Technology Model

[edit] References

[edit] External links

• Arn�¡iz E, Almkvist O - Neuropsychological features of mild cognitive impairment and preclinical Alzheimer's disease
• Budson AE, Price BH - Memory dysfunction
• Cabeza R - Hemispheric asymmetry reduction in older adults: the HAROLD model
• Hedden T, Gabrieli JD - Insights into the ageing mind: a view from cognitive neuroscience
• Henry JD, MacLeod MS, Phillips LH, Crawford JR (March 2004). "A meta-analytic review of prospective memory and aging". Psychol Aging 19 (1): 27'39. doi:10.1037/0882-7974.19.1.27. PMID 15065929. http://content.apa.org/journals/pag/19/1/27. 
• Isaacowitz DM, Wadlinger HA, Goren D, Wilson HR - Selective preference in visual fixation away from negative images in old age? An eye-tracking study
• Johnson MK, Hashtroudi S, Lindsay DS - Source monitoring
• Mather M, Carstensen LL - Aging and motivated cognition: the positivity effect in attention and memory
• Maylor, E.A. (1995). "Prospective memory in normal ageing and dementia". MRC CBU, Cambridge â» Bibliography. http://www.mrc-cbu.cam.ac.uk/bibliography/articles/3356/. 
• Mitchell KJ, Johnson MK, Raye CL, Mather M, D'Esposito M - Aging and reflective processes of working memory: binding and test load deficits
• National Institutes of Health - Memory related resources
• Nilsson LG - Memory function in normal aging